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Radiation Therapy for Mesothelioma
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Katie Duquette

Reading Time: 1 mins

Published On: May 15, 2024

Page Features:21 cited research

Katie Duquette - editor

Katie Duquette, Esquire, edits our legal and medical content. She works as a clinical research coordinator in neurology at Thomas Jefferson University and received her law degree in 2016 from Villanova University School of Law. She is a licensed attorney in the District of Columbia.

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Radiation Therapy for Mesothelioma

Woman Receiving Radiation Therapy

Radiation therapy is a cornerstone of mesothelioma treatment, the cancer that is nearly exclusively caused by asbestos exposure and affects about 3,000 people each year. Radiation therapy uses high-energy radiation to kill cancer cells and shrink tumors making it advantageous in symptom control and improvement of the quality of life.

How Radiation Therapy Works

Although radiation therapy is not meant to cure mesothelioma, it shrinks tumors and reduces pain, making them a crucial part of the comprehensive care for mesothelioma patients. On a cellular level, radiation interferes with the way cancer cells divide and multiply by damaging the DNA in these cells.

Types of Radiation Therapy

The type of radiation therapy that is employed in the treatment of mesothelioma is influenced by several factors such as stage, location, and overall health condition of the patient.

Technological advances like Intensity-Modulated Radiation Therapy (IMRT) and Image-Guided Radiation Therapy (IGRT) have significantly improved the accuracy and thereby the success rate of radiation therapy.

These include methods for more precisely targeting tumors with narrower margins of error to surrounding healthy tissues, as well as allowing better control over the way radiation beams interact with each other and the tumor.

Benefits of Radiation Therapy

The primary benefits of radiation therapy for patients with mesothelioma include alleviating symptoms meaning that the treatment reduces pain or shortness of breath which improves the quality of your life.

It also shrinks tumors, reducing their size, and making them more operable in addition to being more responsive to chemotherapy. This results in better treatment outcomes.

Also, in palliative care radiation therapy may be an option to treat patients helping to manage symptoms, and alleviate pain. It is especially advantageous in those with late-stage mesothelioma that excluded from other serious treatment options.

Combining Radiation with Other Treatments

Mesothelioma 3-year survival rates pie chart, showing 40% for surgery & chemotherapy, 25% for chemotherapy only, 20% for immunotherapy, 15% for radiation therapy, and 5% for no treatment.

Below are the treatment options for mesothelioma.

Surgery and Chemotherapy

Using radiation therapy alongside other treatments for mesothelioma, including surgery and chemotherapy, provides a comprehensive way to treat the cancer. Compared with delivering these treatments separately, this integrated approach may lead to more effective treatment that can also shrink tumors and improve patient survival.

Typical approaches include radiation before surgery to reduce tumor size or in the adjuvant setting, used following surgery to kill any remaining cancer cells.

Alternative and Complementary Treatments

Complementary or alternative treatments, taken in addition to radiation therapy, may help doctors target more precisely the cancer with fewer side effects. Some key examples include acupuncture, herbal medicine, and nutritional approaches.

These treatments may be used alongside radiation therapy to help the body heal itself, which can soothe the side effects of radiation therapy and also provide you with an overall better sense of well-being to support its natural healing processes.

Palliative Care and Radiation Therapy

This works to palliate symptoms and symptomatic relief rather than cure the “disease”. It is used to relieve pain and reduce the size of tumors and it includes sessions of localized radiation delivered precisely to the area that has the cancer, and radiation therapy side effects are managed through supportive care.

The Radiation Therapy Process

The radiation therapy process involves several steps, including planning, simulation, and treatment sessions.

  • Planning: Detailed imaging is used to map the tumor and surrounding tissues.
  • Simulation: Creating a precise treatment plan.
  • Treatment Sessions: Delivering the radiation according to this plan.

Precision and monitoring are crucial throughout the process to ensure optimal outcomes.

Potential Radiation Therapy Side Effects 

Radiation therapy can have side effects such as fatigue, skin irritation, and nausea. Approaches that can help manage these side effects are good nutrition, hydration, and rest. Monitoring of the patient and follow-up care is equally important in case there are any complications, to take care of them.

Factors such as cancer stage, tumor location, and how healthy the patient are also used to determine who is eligible for the treatment.

FAQ: Mesothelioma Radiation Therapy

Below are some common questions patients may have with their doctor or specialist regarding radiation therapy treatment for mesothelioma.

How does radiation therapy specifically target mesothelioma cells?

Radiation therapy targets mesothelioma cells by damaging their DNA, preventing them from dividing and growing. This process involves directing high-energy beams at the tumor site, which disrupts the cancer cells’ ability to reproduce.

Can radiation therapy be used independently for treating mesothelioma?

While radiation therapy can be used independently, it is often combined with other treatments such as surgery and chemotherapy for optimal results. The combination of treatments helps in maximizing the overall effectiveness and improving patient outcomes.

What technological advances have improved radiation treatment for mesothelioma?

Advances such as IMRT, IGRT, proton therapy, and SBRT have significantly improved the precision and effectiveness of radiation treatment for mesothelioma. These technologies allow for more accurate targeting of tumors, minimizing damage to surrounding healthy tissues.

How do doctors decide on the appropriateness of radiation for different stages of mesothelioma?

Doctors assess factors such as cancer stage, tumor location, and overall health to determine the appropriateness of radiation therapy for each patient.

What preparations are necessary before undergoing radiation therapy for mesothelioma?

Preparations include detailed imaging, treatment planning, and simulation to ensure precise targeting of the tumor. This often involves various imaging techniques to map the tumor accurately.

How long does a typical radiation therapy course last for mesothelioma patients?

A typical radiation therapy course lasts several weeks, with sessions scheduled five days a week. Each session usually lasts a few minutes, but the overall treatment duration depends on the specific treatment plan.

Are there any long-term health impacts after completing radiation-targeted therapy?

Long-term health impacts can include fatigue, skin changes, and, in some cases, secondary cancers. Regular follow-up care is essential for monitoring and managing these effects.

What are the latest guidelines for radiation therapy in treating mesothelioma?

The latest guidelines emphasize the importance of personalized treatment plans, advanced technologies, and a multidisciplinary approach to optimize outcomes. These guidelines often recommend the use of advanced radiation techniques like IMRT and proton therapy for precise targeting of tumors and suggest integrating radiation with other treatments such as surgery and chemotherapy for improved results.

How do radiation therapy success rates compare with other treatments for mesothelioma?

Radiation therapy success rates vary based on factors such as cancer stage and overall health. It is often most effective when combined with other treatments like surgery and chemotherapy. In some cases, radiation therapy can significantly improve symptoms and extend survival, particularly when used as part of a comprehensive treatment plan.

What options are available if radiation therapy does not achieve the expected results?

If radiation therapy does not achieve the expected results, options may include additional treatments such as surgery, chemotherapy, or participation in clinical trials for new therapies. Ongoing research and clinical trials continue to explore new and innovative treatments for mesothelioma, offering hope for improved outcomes.

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